{"id":14143,"date":"2022-07-26T14:28:40","date_gmt":"2022-07-26T12:28:40","guid":{"rendered":"https:\/\/fondation-cnrs.org\/crispr-knockout-ko-screens-have-identified-host-factors-regulating-replication-of-severe-acute-respiratory-syndrome-coronavirus-2-sars-cov-2\/"},"modified":"2025-01-22T12:10:20","modified_gmt":"2025-01-22T10:10:20","slug":"crispr-knockout-ko-screens-have-identified-host-factors-regulating-replication-of-severe-acute-respiratory-syndrome-coronavirus-2-sars-cov-2","status":"publish","type":"post","link":"https:\/\/fondation-cnrs.org\/en\/crispr-knockout-ko-screens-have-identified-host-factors-regulating-replication-of-severe-acute-respiratory-syndrome-coronavirus-2-sars-cov-2\/","title":{"rendered":"CRISPR knockout (KO) screens have identified host factors regulating replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)."},"content":{"rendered":"<h2 dir=\"ltr\" style=\"line-height: 1.27273;\">Identification of host factors regulating replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).<\/h2>\n<p class=\"MsoNormal\" style=\"text-align: justify;\">With support from the <strong>CNRS Foundation<\/strong>, <span style=\"mso-fareast-font-family: 'Times New Roman'; color: black;\"><strong>Caroline Goujon<\/strong>, an Inserm research fellow working at the CNRS <strong><span style=\"font-size: 12pt;\">Institut de Recherche en Infectiologie in Montpellier<\/span><\/strong><\/span><strong>,<\/strong> and her colleagues have obtained major results in the identification of human genes regulating replication of the coronavirus responsible for the Covid-19 epidemic, SARS-CoV-2.<\/p>\n<p class=\"MsoNormal\" style=\"text-align: justify;\">Some of the genes identified <strong>also modulate replication of the<\/strong> highly pathogenic Middle East Respiratory Syndrome <strong>Coronavirus<\/strong> (MERS-CoV) and seasonal human coronaviruses (HCoV), responsible for colds every winter. These results contribute to our understanding of SARS-CoV-2 replication and provide a list of potential targets for therapeutic interventions. <\/p>\n<p class=\"MsoNormal\"><span style=\"mso-fareast-font-family: 'Times New Roman'; color: black;\">An article has just appeared in the prestigious journal <strong>Nature Genetics<\/strong> &#8220;Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal HCoVs&#8221;.<\/span><\/p>\n<p class=\"MsoNormal\"><a href=\"https:\/\/www.nature.com\/articles\/s41588-022-01110-2\"><span style=\"mso-fareast-font-family: 'Times New Roman'; color: purple;\">https:\/\/www.nature.com\/articles\/s41588-022-01110-2<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>With support from the CNRS Foundation, Caroline Goujon, an Inserm research fellow working at the CNRS Institut de Recherche en Infectiologie in Montpellier, and her colleagues have obtained major results in the identification of human genes regulating replication of the coronavirus responsible for the Covid-19 epidemic, SARS-CoV-2.  <\/p>\n","protected":false},"author":5,"featured_media":13782,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[73],"tags":[],"class_list":["post-14143","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-archives-en"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.9 (Yoast SEO v25.9) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>CRISPR knockout (KO) screens have identified host factors regulating replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). - CNRS Foundation<\/title>\n<meta name=\"description\" content=\"With support from the CNRS Foundation, Caroline Goujon, an Inserm research fellow working at the CNRS Institut de 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